Photodynamic treatment of red blood cells with phthalocyanines a

Details Photodynamic treatment of red blood cells with phthalocyanines a Photodynamic treatment of red blood cells with phthalocyanines a

1995-03-29

1997-06-10

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

435238, 424 9373, A01N 102, A01N 6300, C12N 706

Patent

active

056374518

ABSTRACT:
An improved process for inactivating an extracellular lipid enveloped virus or an intracellular lipid enveloped virus which may be present in an extracorporeal composition containing red blood cells by subjecting the composition to a virucidally effective amount of a phthalocyanine compound and red light of a fluence rate of at least above about 5 mW/cm.sup.2. Quite contrary to what would have been expected, it has been found that higher light fluence rates are, in fact, more protective of red blood cells than are lower light fluence rates.

REFERENCES:
patent: 5120649 (1992-06-01), Horowitz et al.
patent: 5232844 (1993-08-01), Horowitz et al.
Ben-Hur E et al, 22nd Annual Meeting of The Am. Soc. for Photobiology in Photochem & Photobiol. 59: 74S-75S (1994).
Ben-Hur E et al, Cancer Lett 30: 321-27 (1986).

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