Surgery – Miscellaneous – Methods
Patent
1997-08-19
1998-07-07
Lewis, Aaron J.
Surgery
Miscellaneous
Methods
607 88, 607901, A61B 1900
Patent
active
057753393
ABSTRACT:
The present invention involves the use of a photosensitive texaphyrin for the photodynamic treatment of a pigmented lesion, such as a melanodermic lesion, or a lesion obscured by pigmented tissue such as melaniferous tissue in a subject. In particular, the invention provides a treatment for the metastatic process of melanoma, and a method for inhibiting growth of established metastases of melanoma. The photosensitive texaphyrin may be a free-base texaphyrin or may be metallated with a diamagnetic metal. Preferably, the texaphyrin is metallated with lutetium. Heretofore, melanoma has been refractory to treatment with photodynamic therapy.
REFERENCES:
patent: 4935498 (1990-06-01), Sessler et al.
patent: 5252720 (1993-10-01), Sessler et al.
patent: 5457183 (1995-10-01), Sessler et al.
patent: 5576013 (1996-11-01), Williams et al.
Baumal, et al., "Photodynamic Therapy (PDT) of Experimental Choroidal Neovascularization with Tin Ethyl Etiopurpurin," Investigative Ophthalmology & Visual Science, vol. 37, No. 3, Feb. 15, 1996.
Henderson, et al., "How does Photodynamic Therapy Work?" Photochemistry and Photobiology, vol. 55, No. 1, pp. 145-157, 1992.
Kliman, et al., "Phthalocyanine Photodynamic Therapy: New Strategy for Closure of Choroidal Neovascularization," Lasers in Surgery and Medicine, 15:2-10, 1994.
Kliman, et al., "Retinal and Choroidal Vessel Closure Using Phthalocyanine Photodynamic Therapy," Lasers in Surgery and Medicine, 15:11-18, 1994.
Levy, Julia G., "Photosensitizers in Photodynamic Therapy," Seminars in Oncology, vol. 21, No. 6, Suppl. 15 (Dec.), pp. 4-10, 1994.
Miller, et al., "Phthalocyanine Photodynamic Therapy of Experimental Iris Neovascularization," Ophthalmology, vol. 98, No. 11, pp. 1711-1719, Nov. 1991.
Morgan, et al., "Tin (IV) Etiopurpurin dichloride: An Alternative to DHE?" SPIE vol. 847 New Directions in Photodynamic Therapy, pp. 172-179, 1987.
Young, et al., "Lutetium Texaphyrin (PCI-0123): A Near-Infrared Water-Soluble Photosensitizer," Photochemistry and Photobiology, 63(6), pp. 892-897, 1996.
Andreoni, et al., "B16 melanoma response in vivo to photochemotherapy with mitoxantrone and red light," Cancer Letters, 61, pp. 89-94, 1991.
Sessler et al., "Texaphyrins: Synthesis and Applications," Accounts of Chemical Research, 27(2):43-50, 1994.
Leff, "Texas `Son-of-Porphyrin` Molecule Lassos Europium to Kill Drug Resistance Gene," BioWorld Today, 5(156):1, 1994.
Young et al., "Preclinical Evaluation of Gadolinium (III) Texaphyrin Complex. A New Paramagnetic Contrast Agent for Magnetic Resonance Imaging," Investigative Radiology, 29(3):330-338, 1994.
Furuta et al., "Enhanced Transport of Nucleosides and Nucleoside Analogues with Complementary Base-Pairing Agents," Journal of the American Chemical Society, 113:4706-4707, 1991.
Sessler et al., "Anion Binding: A New Direction In Porphyrin-Related Research," Pure & Applied Chem., 65(3):393-398, 1993.
Sessler et al., "Synthesis and Binding Properties of Monomeric and Dimeric Guanine and Cytosine Amine Derivatives," J. Org. Chem., 1992, 57:818-826.
T.D. Mody et al., "Lutetium (III) Texaphyrin: A Novel Photodynamic Therapy Agent," Abstract, 22nd Annual American Society for Photobiology, Scottsdale, AZ, Jun. 25-29, 1994.
Sessler et al., "Gadolinium (III) Texaphyrin: A Novel MRI Contrast Agent," Journal of the American Chemical Society, 115(22):10368-10369, 1993.
Iverson et al., "Interactions Between Expanded Porphyrins and Nucleic Acids," Pure Applied Chemistry, 66(4):845-850, 1994.
Magda et al., "Site-Specific Hydrolysis of RNA by Europium (III) Texaphyrin Conjugated to a Syntheitc Oligodeoxyribonucleotide," Journal of the American Chemical Society, 116(16):7439-7440, 1994.
Koenig et al., "PDT of Tumor-Bearing Mice Using Liposome Delivered Texaphyrins," International Conference, Milan, Italy, Biosis citation only, Jun. 24-27, 1992.
Mastruzzo et al., "Targeted Photochemical Modification of HIV-Derived Oligoribonucleotides by Antisense Oligodeoxynucleotides Linked to Porphyrins,"Photochemistry and Photobiology, vol. 60, No. 4, pp. 316-322, 1994.
Dougherty, "Photosensitizers: Therapy and Detection of Malignant Tumors", Photochem. Photobiol., 45:879-889, (1987).
Magda et al., "Sequence-Specific Photocleavage of DNA by an Expanded Porphyrin with Irradiation Above 700nm," J. Am. Chem. Soc., 117:3629-3630, 1995.
Sessler et al., "Expanded Porphyrins. Receptors for Cationic, Anionic, and Neutral Substrates," in Transition Metals in Supramolecular Chemistry, L. Fabbrizzi and A. Poggi, Editors, NATO ASI Series, Kluwer, Amsterdam, pp. 391-408, 1994.
PCT Search Report mailed Feb. 23, 1995.
International Search Report mailed Dec. 6, 1994.
International Search Report mailed Feb. 22, 1994.
International Search Report mailed Feb. 3, 1994.
Ehrenberg et al., "Spectroscopy, Photokinetics and Cellular Effect of Far-Red and Near Infrared Absorbing Photosensitizers," Proc. SPIE-Int. Soc. Opt. Eng 1992, 1645 (Proc. Opt. Methods Tumor Treat. Dect.: Mech. Tech. Photodyn. Ther . . ., 259-263, 1992.
Thaller et al., "Potential Use of Radiolabelled Porphyrins for Tumor Scanning," Porphyrin Photosensitization, Kessel and Dougherty, Eds., Plenum Press, New York and London, Pubisher, pp. 265-278, 1981. Edition; published by J.B. Lippincott Company, Philadelphia, pp. 2661-2666 and p. 19 of the index, 1993.
Brown and Truscott, "New Light on Cancer Therapy," Chemistry in Britain, 955-958, 1993.
Ehrenberg et al., "The Binding and Photosensitization Effects of Tetrabenzoporphyrins and Texaphyrin in Bacterial Cells," Lasers in Medical Science, 8:197-203, 1993.
Morgan and Skalkos, "Second Generation Sensitizers: Where are We and Where Should We Be Going?" Proc. SPIE Int. Soc. Opt. Eng. Ser., 6:87-106, 1990.
Horstman, "Study to examine skin cancer drug activated by light," Stanford University Campus Report, Mar. 1996.
Biolo, et al., "Photodynamic Therapy of B16 Pigmented Melanoma With Liposome-Delivered Si(IV)-Naphthalocyanine," Photochemistry and Photobiology, vol. 59, No. 3, pp. 362-265, 1994.
Haylett, et al., "Pharmacokinetic and therapeutic outcome in melanoma cells, of the administration of symmetric and asymmetric cationic photosensitizers," Cancer Letters 88, pp. 191-199, 1995.
Leunig, et al., "Tumour localisation kinetics of photofrin and three synthetic porphyrinoids in an amelanotic melanoma of the hamster," Br. J. Cancer, 68, pp. 225-234, 1993.
Menon, et al., "Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds," Cancer Letters 95, pp. 221-225, 1995.
Nannmark, et al., "Microvessel Origin and Distribution in Pulmonary Metastases of B16 Melanoma: Implication for Adoptive Immunotherapy," Cancer Research 55, pp. 4627-4632, Oct. 15, 1995.
Nelson, et al., "Photodynamic Therapy of Human Malignant Melanoma Xenografts in Athymic Nude Mice," Journal of the National Cancer Institute, vol. 80, No. 1, Mar. 2, 1988.
Sealy, et al., "Photosensitization of Melanin: An Electron Spin Resonance Study of Sensitized Radical Production and Oxygen Consumption," Photochemistry and Photobiology, vol. 40, No. 4, pp. 453-459, 1984.
"Skin Cancer," Canstat, No. 20, pp. 1-15, Mar. 1995.
Dialog Search, 1996.
Search, 1996.
PCT/US90/01208 Int'l Search Report mailed Aug. 2, 1990.
PCT/US95/12312 International Search Report mailed Feb. 9, 1996.
Konig et al., "PDT of Tumor-Bearing Mice Using Liposome Delivered Texaphyrins", International Conference on Photodynamic Therapy and Medical Laser Applications, Milan, Italy, Photodynamic Therapy and Biomedical Lasers, ed. Spinelli et al., Elsevier Science Publishers B.V., pp. 802-805, 1992.
Konig et al., "Photodynamic Activity of Liposome-Delivered Cd-Texaphyrin Using Tumor-Bearing Nude Mice", Lasers in Surgery and Medicine 13:522-527, 1993.
U.S. Serial No. 08/196,964 to Sessler et al. filed Feb. 15, 1994.
U.S. Serial No. 08/227,370 to Sessler et al. filed Apr. 14, 1994.
U.S. Serial No. 08/207,845 to Sessler et al. filed Mar. 8, 1994.
U.S. Serial No. 08/236,218 to Sessler et al. filed Apr. 28, 1994.
U.S. Serial No. 08/310,501 to Sessler et al. filed Sep. 21, 1994.
U.S. Serial No. 08/433,573 to S
Fan Qing
Woodburn Kathryn W.
Young Stuart W.
Lewis Aaron J.
O'Hara Kelly
Pharmacyclics Inc.
LandOfFree
Photodynamic therapy of pigment-related lesions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Photodynamic therapy of pigment-related lesions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Photodynamic therapy of pigment-related lesions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1195614