Photodynamic therapy of occult age-related macular degeneration

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S410000

Reexamination Certificate

active

08034803

ABSTRACT:
The invention relates to the selection and treatment of subjects afflicted with occult choroidal neovascular lesions, including subjects with age-related macular degeneration, by use of photo dynamic therapy (PDT).

REFERENCES:
patent: 5798349 (1998-08-01), Levy et al.
patent: 5935942 (1999-08-01), Zeimer
Drug Facts and Comparison 1999, p. 3987.
TAP Report 1, (“Photodynamic Therapy of Subfoveal Choroidal Neovascularization in Age-related Macular Degeneration with Verteporfin.” Arch Ophtalmol.1999; 117:1329-1345) (the TAP Report).
Reg # 129497-78-5, ACS copyright 2005.
Costa, R. et al. “Photodynamic Therapy with Indocyanine Green for Occult Subfoveal Choroidal Neovascularization Caused by Age-Related Macular Degeneration” [Abstract] Current Eye Research 23(4):271-275 (2001).
Husain, D. et al “Photodynamic Therapy of Exudative Age-Related Macular Degeneration” Seminars in Opthalmology 12(1):14-25 (1997).
Macular Photocoagulation Study Group. “Subfoveal Neovascular Lesions in Age-Related Macular Degeneration” Arch. Opthalmol 109:1242-1257 (1991).
Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) Study Group. “Photodynamic Therapy of Subfoveal Choroidal Neovascularization” Arch. Opthalmol. 117(10):1329-1345 (1999).
Verteporfin in Photodynamic Therapy Study Group: “Verteporfin Therapy of Subfoveal Choroidal Neovascularization in Age-Related Macular Degeneration: Two-Year Results of a Randomized Clinical Trial Including Lesions with Occult with No Classic Choroidal Neovascularization: Verteporfin in Photodynamic Therapy Report 2” American Journal of Opthalmology 131(5):541-560 (2001).
Wormald, R. et al. “Photodynamic Therapy for Neovascular Age-Related Macular Degeneration” [Abstract] Cochrane Database of Systematic Reviews (Online: Update Software) England 2000 2:CD002030 (2000).

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