Photodynamic therapy for the treatment of osteoarthritis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514561, 514429, 514825, A01N 4338

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active

059425342

ABSTRACT:
A method of treating a patient who has osteoarthritic disease by administering a therapeutic composition containing a photoactivatable compound, or a precursor thereof, and administering light of a photoactivating wavelength that activates the compound.

REFERENCES:
patent: 5028594 (1991-07-01), Carson
patent: 5079262 (1992-01-01), Kennedy et al.
patent: 5211938 (1993-05-01), Kennedy et al.
patent: 5234940 (1993-08-01), Kennedy et al.
patent: 5368841 (1994-11-01), Trauner et al.
patent: 5422093 (1995-06-01), Kennedy et al.
Allison et al., "The Plasma Distribution of Benzoporphyrin Derivative And The Effects of Plasma Lipoproteins On Its Biodistribution," Photochem. Photobiol. 52: 501-507 (1990).
Allison et al., "The Effects of Plasma Lipoproteins On In Vitro Tumor Cell Killing And In Vivo Tumor Photosensitization With Benzoprophyrin Derivative," Photochem. Photobiol. 54: 709-715 (1991).
Auler et al., "Untersuchungen uber die Rolle der Porphyrine bei geschwulstkranken Menschen und Tierch," Z. Krebforsch 53: 65-68 (1942).
Beems et al., "Photosensitization Properties of Bacteriochlorophyllin .alpha. And Bacteriochlorin .alpha., Two Derivatives of Bacteriochlorophyll .alpha.," Photochem. Photobiol. 46: 639-643 (1987).
Bottiroli et al., "Equilibrium Among Hematoporphyrin-Derivative Components: Influence of The Interaction With Cellular Structures," Photochem. Photobiol. 47: 209-214 (1988).
Brault, "Physical Chemistry of Porphyrins And Their Interactions With Membranes: The Importance of pH," J. Photochem. Photobiol, B: Biology 6: 79-86 (1990).
Dougherty et al., "Photodynamic Therapy For The Treatment of Cancer: Current Status And Advances," Photodynamic Therapy of Neoplastic Disease, Kessel Ed., chapter 1: 1-19 (1989).
Figge et al., "Cancer Detection And Therapy. Affinity of Neoplastic, Embryonic, And Traumatized Tissues For Porphyrins And Metalloporphyrins," Proc. Soc. Exp. Biol. Med. 68: 640-641 (1948).
Gomer, "Preclinical Examination of First and Second Generation Photosensitizers Used In Photodynamic Therapy" Photochem. Photobiol. 54: 1093-1107 (1991).
Gross, "Spectroscopic Determination of Hematoporphyrin-Membrane Partition Parameters," Photobiological Techniques, Series A: Life Sciences 216: 117-126 Plenum Press, New York (1991).
Gurinovich et al., Photodynamic Activity of Chlorin e.sub.6 and Cholorin e.sub.6 Ethylenediamide In Vitro and In Vivo J. Photochem. Photobiol. B: Biol. 13: 51-57 (1992).
Henderson et al., "Studies On The Mechanism of Tumor Destruction By Photoradiation Therapy," Porphyrin Localization and Treatment of Tumors, Liss, New York pp. 601-612 (1984).
Jori et al., "Strategies For Tumor Targeting By Photodynamic Sensitizers," Photodynamic Therapy of Neoplastic Disease, 2: 117-130 (1989).
Jori et al., "Photothermal Sensitizers: Possible Use In Tumor Therapy," J. Photochem. Photobiol. B: Biology 6: 93-101 (1990).
Kessel, "Sites of Photosensitization By Derivatives of Hematoporphyrin," Photochem. Photobiol 44: 489-493 (1986).
Kessel, "Interactions Between Porphyrins And Mitochondrial Benzodiazepine Receptors," Cancer Letters 39: 193-198 (1988).
Kessel et al., "Photosensitization With Derivatives of Chlorophyll," Photochem. Photobiol 49: 157-160 (1989).
Kessel, "Determinants of Photosensitization By Purpurins," Photochem. Photobiol. 50: 169-174 (1989).
Kreimer-Birnbaum, "Modified Porphyrins, Chlorins, Phthalocyanines, and Purpurins: Second-Generation Photosensitizers for Photodynamic Therapy," Sem. in Hematol. 26: 157-173 (1989).
Lipson et al., "The Use of A Derivative of Hematoporphyrin In Tumor Detection," JNCI 26: 1-10 (1961).
Maziere et al., "Cellular Uptake And Photosensitizing Properties of Anticancer Porphyrins In Cell Membranes And Low And High Density Lipoproteins," J. Photochem. Photobiol., B: Biology 6: 61-68 (1990).
Maziere et al., "New Trends In Photobiology (Invited Review) The Role Of The Low Density Lipoprotein Receptor Pathway In The Delivery of Lopophilic Photosensitizers In The Photodynamic Therapy of Tumours," J. Photochem. Photobiol., B: Biology 8: 351-360 (1991).
Morgan et al., "New Sensitizers for Photodynamic Therapy: Controlled Synthesis of Purpurins And Their Effect On Normal Tissue," J. Med. Chem. 32: 904-908 (1989).
Morgan et al., "Metallopurpurins And Light: Effect On Transplantable Rat Bladder Tumors And Murine Skin," Photochem. Photobiol. 51: 589-592 (1990).
Poon et al., "Laser-Induced Fluorescence: Experimental Intraoperative Delineation of Tumor Resection Margins" J. Neurosurg 76: 679-686 (1992).
Pottier, "In Vitro And In Vivo Fluorescence Monitoring of Photosensitizers," J. Photochem. Photobiol, B: Biology 6: 103-109 (1990).
Ricchelli et al., "Factors Influencing The Distribution Pattern of Porphyrins In Cell Membranes," J. Photochem. Photobiol., B: Biology 6: 69-77 (1990).
Reddi et al., "Liposome- or LDL- Administered Zn (II)--Phthalocyanine As A Photodynamic Agent For Tumours. I. Pharmacokinetic Properties And Phototherapeutic Efficiency," Br. J. Cancer 61: 407-411 (1990).
Richter et al., "Photosensitizing Potency of Structural Analogues of Benzoporphyrin Derivative (BPD) In A Mouse Tumour Model," Br. J. Cancer 63: 87-93 (1991).
Salet, et al., "Photosensitization of Isolated Mitochondria By Hematoporphyrin Derivative (PhotoFrin.RTM.): Effects On Bioenergetics," Photochem. Photobiol. 53: 391-393 (1991).
Weishaupt, et al., "Identification of Singlet Oxygen As The Cytotoxic Agent In Photo-Inactivation of A Murine Tumor," Cancer Research 36: 2326-2329 (1976).

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