Photodynamic therapy for the destruction of the synovium in the

Details Photodynamic therapy for the destruction of the synovium in the Photodynamic therapy for the destruction of the synovium in the

1993-02-11

1994-11-29

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

514183, 514825, 540145, A61K 4900, A61K 3133

Patent

active

053688414

ABSTRACT:
A method of treating proliferative diseases of the synovial joint using photodynamic therapy. In particular the method of the invention may be used to destroy synovial tissue in inflammatory joint conditions associated with diseases such as rheumatoid arthritis, lupus erythematosus and other rheumatoid variants. A number of methods of delivery are provided, some of which are non invasive.

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Dougherty et al., Photodynamic Theraphy for the Treatment of Cancer: Current Status and Advances, In Photodyanmic Therapy of Neoplastic Disease, Kessel ed., (CRC Press, Boca Raton, Fla.) vol. 1, pp. 2-19, 1989.
Sledge et al., Intra-articular Radiation Synovectomy, Clinical Orthopaedics and Related Research 182:37-40, 1984.
Zuckerman et al., Treatment of Antigen-induced Arthritis in Rabbits with Dysprosium 165-Ferric Hydroxide Macroaggregates, J. Orthopaedic Research 7:50-60, 1989.

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