Photodynamic inactivation of viruses in cell-containing composit

Details Photodynamic inactivation of viruses in cell-containing composit Photodynamic inactivation of viruses in cell-containing composit

1991-05-29

1993-08-03

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

435236, 4351733, 435 2, 424 90, 424529, 424533, C12N 1300, C12N 704, A61K 3936

Patent

active

052328449

ABSTRACT:
The present invention concerns the product produced by inactivating extracellular lipid enveloped pathogenic virus or intracellular pathogenic virus in a composition containing >1.times.10.sup.9 cells/ml and said virus without incurring substantial disruption or inactivation of such cells, the inactivation process comprising contacting the composition with a virucidally effective amount of at least one photoreactive compound having an absorption maximum of .gtoreq.630 nm, light and an oxidizer, thereby substantially to inactivate the virus with retention of cell functionality, greater than 80%. The present invention also concerns the product produced by inactivating virus in a biological composition without incurring substantial disruption or inactivation thereof, the inactivation process comprising contacting said composition with a virucidally effective amount of at least one photoreactive compound, light, and a quencher thereby to inactivate said virus while retaining functionality of said substance.

REFERENCES:
patent: 4727027 (1988-02-01), Wiesehahn et al.
patent: 4748120 (1988-05-01), Wiesehahn
patent: 4775625 (1988-10-01), Sieber
patent: 4791062 (1988-12-01), Wiesehahn et al.
patent: 5120649 (1992-06-01), Horowitz et al.
Prince, A. M., Horowitz, B., Horowitz, M. S. and Zang, E., 1987, "The Development of Virus-Free Labile Blood Derivatives-A Review", Eur. J. Epidemiol., 3, 103-118.
Mannucci, P. M. and Colombo, M., 1988, "Virucidal Treatment of Clotting Factor Concentrates", The Lancet, 782-785.
Rosenthal, I. and Ben-Hur, E., 1989, "Phthalocyanines in Photobiology",pp. 393-425, in Lezhoff, C. C. and Lever, A. B. P. (Eds), Phthalocyanines, VCH Publishers, Inc., New York, U.S.A.
Rosenthal, I. and Ben-Hur, E., 1986, "Photohemolysis of Human Erythrocytes Induced by Aluminum Phthalocyanine Tetrasulfonate", Cancer Lett., 30, 321-327.
Sonoda, Krishna and Riesz, 1987, "The Role of Singlet Oxygen in the Photohemolysis of Red Blood Cells Sensitized by Phthalocyanine", Photochem. Photobiol., 46, 625-531.
Cole, M., Stromberg, R., Friedman, L., Benade, L. and Shumaker, J., 1989, "Photochemical Inactivation of Virus in Red Cells", Transfusion, 29, Supp:42s Abs.
Prodouz, K. N., 1989, "Effect of Merocyanine 540 on Platelet Function and Reduction of its Antiviral Activity by Albumin", Transfusion, 29, Supp:42s Abs.
Moroff, G., Benade, L. E., Dabay, M., George, V. M., Shumaker, J. and Dodd, R. Y., 1989, "Use of Photochemical Procedures to Inactivate Viruses in Platelet Suspensions", Transfusion, 29, Supp: S15 Abs.
Matthews, J. T., Newmann, J.T., Songandares-Bernal, F., et al., 1988, "Photodynamic Therapy of Viral Contaminants with Potential for Blood Banking Applications", Transfusion, 28, 81-83.
Lin, L., Wiesehahn, G. P., Morel, P. A. and Corash, J., 1989, "Use of 8-Methoxypsoralen and Long-wavelength Ultraviolet Radiation for Decontamination of Platelet Concentrates", Blood, 74, 517-525.
Wiliams, B., et al., 1988, Blood, 72, Suppl:287a.
Prodouz, K. N., Fratantoni, J.C., Boone, J. E. and Bonner, R. F., 1987, "Use of Laser-UV for Inactivation of Virus in Blood Products", Blood, 70, 589-592.
Hartman, F. W., Mangun, G. H., Feeley, N. and Jackson, E., 1949, "On the Chemical Sterilization of Blood and Blood Products", Proc. Soc. Exp. Biol. Med., 70, 248-254.
LoGrippo, G. A., 1959, "Investigations of the Use of Beta-Propiolactone in Virus Inactivation", Ann NY Acad. Sci., 83, 578-594.
Spikes, J., 1986, "Phthalocyanines as Photosensitizers in Biological Systems and for the Photodynamic Therapy of Tumors", Photochemistry and Photobiology, 43, 691-699.
Ben-Hur, E. and Rosenthal, I., 1989, "The Phthalocyanines: A New Class of Mammalian Cell Photosensitizers with a Potential for Cancer Phototherapy", Int. J. Radiat. Biol., 47, 145-147.
Prince, A. M., Stephen, W., Bortman, B. and van den Ende, M. C., 1980, "Evaluation of the Effect of Beta-Propiolactone/Ultraviolet Irradiation (BPL/UV) Treatment of Source Plasma on Hepatitis Transmission by Factor IX Complex in Chimpanzees", Thrombosis and Hemostasis

Affiliated with

Also associated with

Rating

Photodynamic inactivation of viruses in cell-containing composit does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Photodynamic inactivation of viruses in cell-containing composit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Photodynamic inactivation of viruses in cell-containing composit will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2269865