Photodynamic inactivation of enveloped viruses using buckminster

Details Photodynamic inactivation of enveloped viruses using buckminster Photodynamic inactivation of enveloped viruses using buckminster

1997-03-07

1999-02-02

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

435238, A01N 102, C12N 706

Patent

active

058663169

ABSTRACT:
In a process for the inactivation of enveloped viruses in a biological fluid buckminsterfullerene (C.sub.60) is used as a photosensitizer. In a photodynamic processes singlet oxygen is generated which is the active agent for the inactivation of viruses present in the fluid. The process comprises the steps of (a) contacting of a solution or dispersion of material derived from the human body or from the bodies of animals with buckminsterfullerene as a photosensitizer, of (b) saturating the solution or dispersion with oxygen; and of (c) irradiating the solution or dispersion with visible or invisible light for activating the oxygen into the singlet state until viruses contained in the solution or dispersion are inactivated. This virus inactivation is specially suitable for protein solutions, e.g. bovine serum albumin, BSA or plasma products of human origin.

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