Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1995-02-09
1997-06-10
Spivack, Phyllis G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
546 18, 549 10, 549 11, 549331, 549334, 549344, 549345, 549399, 549400, 549404, 549406, C07D24138, C07D45114, C07D47114, C07D31196
Patent
active
056377096
ABSTRACT:
Polychromatic compounds of pyrans having a substituted adamantane or a polycyclic ring system, with the exception of adamantane, in the 2-position of the pyran ring, having the structure ##STR1## whereby the residues R.sub.1 -R.sub.4 are independently substituents selected from the series H, alkyl, substituted phenyl, phenyl, naphthyl, OH, alkoxy (C.sub.1 -C.sub.4), halogen, alkylamino, dialkylamino, cyan, trifluormethyl, or, R.sub.1 and R.sub.2 or R.sub.3 and R.sub.4 or R.sub.2 and R.sub.3 are constituents of at least one condensed aromatic, heteroaromatic or an alkane ring, wherein said heteroaromatic ring is selected from the group consisting of pyridine, pyrimidine, pyridazine, quinoline, isoquinoline, naphthyridine, quinazoline, quinoxaline, phthalazine, pteridine, phenazine, and benzoquinoline which are substituted by the same residues as R.sub.1 -R.sub.4 above, and wherein the polycyclic ring system is not adamantane and the substituted adamantane contains one or two oxygen, nitrogen or sulfur atoms replacing one or two carbon atoms or is substituted with one or two alkyl moieties.
REFERENCES:
Thornber, "Isosterism and Molecular Modification in Drug Design", Chemical Society Reviews 8(4) 1979 563-580.
Optische Werke G. Rodenstock
Spivack Phyllis G.
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