Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-05-16
1991-03-19
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C07D49306
Patent
active
050011472
ABSTRACT:
The alkylangelicins according to the invention are obtained starting from an umbelliferone, in which the 6-position is already substituted by an alkyl group; in such a way the 7-allyloxy or 7-acyloxy umbelliferone intermediates can form by transposition of the allyl or acyl group only the 8-allyl and 8-acyl derivatives, and therefore the presence, even in traces, of psoralens is absolutely excluded in the subsequent synthetic steps.
The 6-alkylangelicins thus obtained are particularly usable for the photochemotherapy of psoriasys and of other skin diseases characterized by cellular hyperproliferation, as well as for the photochemotherapy of vitiligo and of alopecia aerata.
REFERENCES:
patent: 4312883 (1982-01-01), Baccichetti et al.
Guiotto et al. CA 96:68692q.
Dall'Acqua et al. CA 94:58098v.
Danan et al. CA 96:85300c.
Baccichetti Francarosa
Bordin Franco
Bragadin Carlo M.
Carlassare Francesco
Cristofolini Mario
Consiglio Nazionale Delle Ricerche
Fan Jane T.
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