Photochemotherapeutic method using 5-aminolevulinic acid and pre

Details Photochemotherapeutic method using 5-aminolevulinic acid and pre Photochemotherapeutic method using 5-aminolevulinic acid and pre

1993-06-28

1995-06-06

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Diagnostic or test agent produces in vivo fluorescence

514410, 514561, 514814, 514843, 514899, 540145, 562567, A61K 4900

Patent

active

054220939

ABSTRACT:
A method of detecting and treating malignant and non-malignant tissue abnormalities and lesions of the skin; conjunctiva; respiratory, digestive and vaginal mucosa; endometrium and urothelium; and for ablating the endometrial tissue and treating body fluids, including blood containing suspended abnormal cells, and for treating cancers of the nervous system in which 5-aminolevulinic acid or precursor thereof is administered to the patient in an amount sufficient to induce synthesis fluorescence and/or photosensitizing concentrations of a protoporphyrin IX in the abnormal cells, followed by exposure of the abnormal cells to light of photoactivating wavelengths.

REFERENCES:
patent: 5079262 (1992-01-01), Kennedy et al.
patent: 5127938 (1992-07-01), Rebeiz
patent: 5163990 (1992-11-01), Rebeiz
patent: 5200427 (1993-04-01), Rebeiz
patent: 5211938 (1992-05-01), Kennedy et al.
patent: 5234940 (1992-04-01), Kennedy et al.
Bickers et al., J. Inv. Derm 68:5-9 (1977).
Berlin, et al., "The Metabolism of Aminolevulinc Acid" Parts I and II Biochem J. 64:80-90, 90-100 (1956).
Malik, et al., Br. J. Cancer 56(5): 589-(Nov. 1987).
Kennedy et al. "Photodynamic Therapy With Endogenous Protoporphyrin IX: Basic Principles and Presetn Clinical Experience", J. Photochem. Photobiol. 6:143-148 (1990).

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