Photochemically-removable silyl protecting groups

Details Photochemically-removable silyl protecting groups Photochemically-removable silyl protecting groups

1994-11-10

1996-01-23

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

556413, 556424, 556426, 556429, 556449, 549214, C07F 708, C07F 710

Patent

active

054866332

ABSTRACT:
The present invention relates, in general, to photochemically removable protecting groups, and, in particular, to the use of styrylsilyl groups to protect reactive functional groups, such as, hydroxyl, amino and thiol groups.

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Pirrung et al, "Photochemically-Removable Silyl Protecting Groups", J. Org. Chem. 58:6961-6963 (1993).
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Lew et al, "Photochemical Protodesilylation of 2-R.sub.3 Si-1,3-dimethoxybenzenes. Direct Observation of .beta.-Silyl-Substituted Cyclohexadienyl Cations", J. Am. Chem. Soc. 115:11516-11520 (1993).
Fodor et al, "Light-Directed, Spatially Addressable Parallel Chemical Synthesis", Science 251:767-773 (1991).
Horne et al, "Recognition of Mixed-Sequence Duplex DNA by Alternate-Strand Triple-Helix Formation", J. Am. Chem. Soc. 112:2435-2437 (1990).

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