Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1990-02-06
1991-06-25
Rollins, John W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 4, 435 6, 435188, 436 63, 436 94, 436501, C07H 1512, C12Q 100
Patent
active
050268406
ABSTRACT:
A photochemical nucleic acid-labeling reagent of the formula ##STR1## wherein Q is a photoreactive residue of a nucleic acid-binding ligand; L is a detectable label residue; R is hydrogen, C.sub.1 to C.sub.7 -alkyl, aryl, hydroxy, or C.sub.1 to C.sub.7 -alkoxy; x is an integer from 2 through 7; and Y is an integer from 3 through 10; wherein R and x, respectively, can be the same or different each time they appear in the formula. The reagent is useful in the highly efficient labeling of nucleic acids for the purpose of detection in hybridization assays.
REFERENCES:
patent: 4582789 (1986-04-01), Sheldon et al.
patent: 4599303 (1986-07-01), Yabusaki et al.
patent: 4617261 (1986-11-01), Sheldon, III et al.
patent: 4737454 (1988-04-01), Dattagupta et al.
Lown et al, "Bis-intercalative Binding to DNA of Novel bis(10-methyl)acridinium Chlorides and Its Dependence on Chain Length of Linker", Can. J. Biochem. 1978, 56(11), 1006-1015.
Hansen et al, "Acridine-psoralen Amines and Their Interaction with DNA", Biochemistry, 22(21), 4878-4886, 1983.
Albarella James P.
Dattagupta Nanibhushan
Molecular Diagnostics, Inc.
Rollins John W.
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