Photochemical decontamination treatment of whole blood or blood

Details Photochemical decontamination treatment of whole blood or blood Photochemical decontamination treatment of whole blood or blood

1986-10-20

1988-05-31

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

424 85, 424 89, 424 90, 424101, 514 2, 514 6, 530380, 530381, 530383, 530387, 530389, 530829, C12N 1300, A61K 3900, A61K 3514, A61K 3548

Patent

active

047481200

ABSTRACT:
Biological compositions are freed of functional polynucleotides by treatment of the biological composition with psoralen derivatives under irradiation conditions in which the proteins retain their original physiological activities and any polynucleotide present is rendered inactive.

REFERENCES:
patent: 4124598 (1978-11-01), Hearst et al.
patent: 4169204 (1979-09-01), Hearst et al.
patent: 4321919 (1982-03-01), Edelson
Musajo et al, Experentia, vol. XXI, pp. 22-24, "Photosensitizing Furocoumanns: Interaction with DNA and Photo-Inactivation of DNA Containing Viruses".
Veronese et al, Photochem Photobiol, vol. 36, pp. 25-30, "Photoinactivation of Enzymes by Linear and Angular Furocoumanns".
De Mol et al., Chem. Abst., vol. 95, No. 74462k, p. 197, 1981, "On the Involvement of Singlet Oxygen in Mutation Induction by 8-Methoxypsoraten and UVA Radiation in Escherichia coli K-12".
De Mol et al, Photochem Photobiol, vol. 33, pp. 815-819, 1981, "Relation Between Some Photobiological Properties of Furocoumanns and their Extent of Singlet Oxygen Formation".
deMol et al. (1981) Photochem. Photobiol. 34:661-666.
Joshi and Pathak (1983) Biochem. Biophys. Res. Comm., 112:638-646.
Grossweiner (1982) NCI Monograph, No. 66, 47-54.
Rodighiero and Dall'Acqua (1982) NCI Monograph, No. 66, 31-40.

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