Photoactivatable water soluble cross-linking agents containing a

Details Photoactivatable water soluble cross-linking agents containing a Photoactivatable water soluble cross-linking agents containing a

1995-11-03

1998-02-03

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

435177, 435181, 436518, 436532, 530810, 530816, 536 111, 568332, C12N 1100, G01N 33549, C07K 1706, C07C 4976

Patent

active

057143609

ABSTRACT:
A chemical linking agent is formed of a di- or higher functional photoactivatable compound having at least one group that is charged under the conditions of use in order to provide improved water solubility. The linking agent contains two or more photoreactive groups in order to allow the agent to be used as a cross-linking agent in aqueous systems. The charged group can be provided by a radical that includes one or more salts of organic acids, onium compounds, or protonated amines, (and optionally one or more additional photoreactive groups) and the photoreactive groups can be provided by two or more radicals that include an aryl ketone. The onium compound can provide a quaternary ammonium, sulfonium or phosphonium group. A surface can be coated with a target molecule such as a synthetic polymer, carbohydrate, protein, lipid, nucleic acid, drug, vitamin, cofactor or dye by forming an aqueous solution of the linking agent and the target molecule, placing the solution in contact with the surface and activating the photoreactive groups of the linking agent to cross-link the target molecule to the surface.

REFERENCES:
patent: 4309453 (1982-01-01), Reiner et al.
patent: 4722906 (1988-02-01), Guire
patent: 4973493 (1990-11-01), Guire
patent: 4979959 (1990-12-01), Guire
patent: 5002582 (1991-03-01), Guire et al.
patent: 5414075 (1995-05-01), Swan et al.
"Polyamines and Polyquaternary Ammonium Salts", pp. 761-763, in Concise Encyclopedia of Polymer Science and Engineering, Kroschwitz, ed., John Wiley and Sons, 1990.
Menschutkin reaction (Z. Physik. Chem. 5, 589 (1890).
Organic Synthesis Collective vol. IV, 585 (1963).
"Plastics", pp. 462-464, in Concise Encyclopedia of Polymer Science and Engineering, Kroschwitz, ed., John Wiley and Sons, 1990.

Affiliated with

Also associated with

Rating

Photoactivatable water soluble cross-linking agents containing a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Photoactivatable water soluble cross-linking agents containing a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Photoactivatable water soluble cross-linking agents containing a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-661462