Photoactivatable cross-linking agents containing charged groups

Details Photoactivatable cross-linking agents containing charged groups Photoactivatable cross-linking agents containing charged groups

1998-01-02

2000-06-20

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

435177, 435181, 436518, 436532, 530810, 530816, 536 111, 568332, C12N 1100, G01N 33549, C07K 1706, C07C 4976

Patent

active

060776986

ABSTRACT:
A chemical linking agent is formed of a di- or higher functional photoactivatable compound having at least one group that is charged to improve water solubility, and two or more photoreactive groups (preferably comprising an aryl ketone such as benzophenone) that allow use of the agent in aqueous systems. Charged groups include salts of organic acids such as sulfonate, phosphonate and carboxylate groups, onium groups such as quaternary ammonium, sulfonium and phosphonium groups, and protonated amines. A surface can be coated with a substance such as a synthetic polymer, carbohydrate, protein, lipid, nucleic acid, drug, vitamin, cofactor or dye by forming an aqueous solution of the linking agent and the substance, placing the solution in contact with the surface and activating the photoreactive groups of the linking agent to cross-link the substance to the surface.

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Kroschwitz, ed., Polyamines and Polyquaternary Ammonium Salts, Concise Encyclopedia of Polymer Science and Engineering, John Wiley & Sons, 1990, pp. 761-763.

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