Photo-potentiation of cisplatin chemotherapy

Details Photo-potentiation of cisplatin chemotherapy Photo-potentiation of cisplatin chemotherapy

1998-01-28

2000-02-29

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 435 723, 4351731, 424617, 424649, C12Q 168, C12N 1300, A01N 5916, A61K 3324

Patent

active

060307838

ABSTRACT:
Methods disclosed herein capitalize on the discovery that DNA Structure Specific Recognition Proteins (SSRPs) can be induced to bind covalently to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents, by photo-irradiation with ultraviolet light. Methods and compositions based on this discovery are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs. Methods and compositions also are provided for potentiating cytotoxicity of a chemotherapeutic agent, particularly a cisplatin-type agent.

REFERENCES:
patent: 5359047 (1994-10-01), Donahue et al.
patent: 5670621 (1997-09-01), Donahue et al.
patent: 5705334 (1998-01-01), Lippard et al.
patent: 5879917 (1999-03-01), Essigmann et al.
"Photoreactivity of Platinum(II) in Cisplatin-Modified DNA Affords Specific Cross-Links to HMG Domain Proteins," Kane et al., Biochemistry, 1996, 35, 2180-2188.
"UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA," Payet et al., Metal-Based Drugs, 1995, 2, 137-161.

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