Photcurable glycosaminoglycan derivatives, crosslinked glycosami

Details Photcurable glycosaminoglycan derivatives, crosslinked glycosami Photcurable glycosaminoglycan derivatives, crosslinked glycosami

1995-06-07

1998-06-09

Berman, Susan W.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Compositions to be polymerized by wave energy wherein said...

522 88, 523105, 527200, 527201, 527312, 527313, 527314, 527315, 514 8, 424447, 424423, 424499, C08G 6400, C08G 6908, C08G 7310, A61K 950

Patent

active

057635048

ABSTRACT:
Photocurable glycosaminoglycan (GAG) derivatives and crosslinked glycosaminoglycans, which are highly safe and biocompatible, a method of preparing such photocurable GAG derivatives readily moldable by casting using a solvent when desired, by which method unreacted substances causative of adverse effects can be readily eliminated, and a method of producing the crosslinked GAGs and medical materials based on the photocurable GAG derivatives or crosslinked GAGs are provided. The photocurable GAG derivatives comprise a glycosaminoglycan and a photoreactive compound bound thereto and can be produced, for example, by subjecting hydroxyl or carboxyl groups of the glycosaminoglycan to esterification reaction or amidation reaction, respectively, with the photoreactive compound. The crosslinked GAGs are derived from the photocurable GAG derivatives by intermolecular crosslinking of the photoreactive compound bound thereto.

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