Phospphine-phosinite compound and process for preparing

Details Phospphine-phosinite compound and process for preparing Phospphine-phosinite compound and process for preparing

1996-07-09

1998-10-20

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus containing

568 14, 540200, C07F 902, C07D20500

Patent

active

058248226

ABSTRACT:
A phosphine-phosphinite compound represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represent a substituted or unsubstituted phenyl group or a substituted or unsubstituted naphthyl group, and a process for preparing a The compound (I), either in combination, or as a complex, with a transition metal compound, is useful as a catalyst for asymmetric hydroformylation and makes it possible to easily synthesize an important intermediate for carbapenem antibiotics or a precursor thereof at high regioselectivity and diastereo-selectivity.

REFERENCES:
patent: 5530150 (1996-06-01), Takaya et al.
Tolman C.A., "Electron Donor--Acceptor . . . ", J. Amer. Chem. Soc., vol. 92(10), May 20, 1970, pp. 2953-2956.
Tolman C.A., "Phosphorus Liggand Exchange . . . ", J. Amer. Chem. Soc., vol. 92(10), May 20, 1970, pp. 2956-2965.
Tolman C.A., "Steric Effects of Phosphorus . . . ", Chemical Reviews, vol. 77(3), 1977, pp. 313-348.
Hobbs et al, Asymmetric Hydroformylation of Vinyl Acetate with DIOP-Type Ligands, 1981, pp. 4422-4427.
Hayashi et al, Catalytic Hydroformylation by th Use of Rhodium-complexes of Chiral Bidentate Phosphorus Ligands Bearing Saturated Ring Skeletons, Sep. 1979 vol. 52 pp. 2605-2608.
Gladiali et al, Completely Regioselective Hydroformylation of Methyl N-Acetamidoacrylate by Chiral Rhodium Phosphine Catalysts, 1990, vol. 1, No. 10 pp. 693-696.
Sakai et al, Asymmetric Hydroformylation of Vinyl Acetate By Use of Chiral Bis(triarylphosphite) Rhodium(I)Complexes, 1992, vol. 3 No. 5 pp. 583-586.
Sakai et al, Highly Enantioselective Hydroformylation of Olefins Catalyzed by New Phosphinephosphite-Rh(I) Complexes, 1993, pp. 7033-7034.

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