Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-05-06
2000-06-06
MacMillan, Keith D
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 794, 530352, 53038826, 4241461, G01N 3353, A61K 3816, C07K 1600
Patent
active
060717076
ABSTRACT:
This invention relates to phosphotyrosine mimics which, when incorporated into an appropriate molecular structure, are capable of inhibiting the binding of tyrosine kinase-dependent regulatory proteins to the native phosphotyrosine-containing receptors. This invention also relates to methods and kits for identifying and using phosphotyrosine mimics. The compounds, kits and methods of this invention are useful for identifying and designing antagonists of tyrosine-kinase dependent regulatory proteins, such as signal transduction proteins containing SH.sub.2 binding domains.
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Gordon et al., Journal of medicinal chemistry., vol. 37., No. 10., pp. 1385-1401, May 1994.
Bin Ye et al., J. Med. Chem., vol. 38., No. 21., pp. 4270-4275., 1995.
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Barton Randall W.
Kennedy Charles A.
Boehringer Ingelheim Pharmaceuticals Inc.
Devlin Mary-Allen M.
MacMillan Keith D
Ponnaluri P.
Raymond Robert P.
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