Phosphotriester type biologically active compounds

Details Phosphotriester type biologically active compounds Phosphotriester type biologically active compounds

1995-04-04

1998-06-23

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2671, 536 2672, 536 2674, 536 268, 536 269, 544243, 544264, C07H 100, C07H 1900

Patent

active

057707251

ABSTRACT:
Compounds of formula RO--P(.dbd.O)(OR)--Nu where: each R is, independently, --(CH.sub.2).sub.n --S--X; X is --C(.dbd.Z) (Y) or --S--U; Z is O or S; Y and U are alkyl, aryl or saccharide groups optionally substituted with OH, SH or NH groups; n is 1 to 4; and Nu is a nucleoside which comprises a ribose or deoxyribose sugar portion covalently bound to a base portion.

REFERENCES:
patent: 5430136 (1995-07-01), Urdea et al.
patent: 5430138 (1995-07-01), Urdea et al.
Hao, Z. et al., "Potent DNA Chain Termination Activity and Selective Inhibition of Human Immunodeficiency Virus Reverse Transcriptase by 2', 3'--Dideoxyuridine-5'-triphosphate", Molecular Pharmacology 1990, 37, 157-163.
Hao, Z. et al, "2', 3'-Dideoxyuridine Triphosphate: A Potent Inhibitor of HIV Reverse Transcriptase", Proceedings of AACR 1988, 29, 348.
Matthes, E. et al., "Inhibition of HIV-Associated Reverse Transcriptase By Sugar-Modified Derivatives of Thymidine 5'-Triphosphate in Comparison to Cellular DNA Polymerases .alpha. and .beta.", Biochemical and Biophysical Research Communications 1997, 148(1), 78-85.
Rosenberg et al., "Synthesis of Potential Prodrugs and Metabolites of 9-(S)-(3-Hydroxy-2-Phosphonylmethoxypropyl)Adenine", Collection Czechoslovak Chem. Comm. 1987, 52, 2792-2800.

Affiliated with

Also associated with

Rating

Phosphotriester type biologically active compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphotriester type biologically active compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphotriester type biologically active compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1395616