Phosphorylation of histone H3 at threonine 11—a novel...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007210

Reexamination Certificate

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08076094

ABSTRACT:
The present invention relates to a process for controlling at least one androgen receptor- (AR-) regulated mechanism in mammalian cells under histone-phosphorylating conditions, said process comprising allowing at least one inhibitor with specificity for at least one protein kinase C-related kinase (PRK) to act on said at least one PRK1 thereby modulating, preferably down-regulating, the activity of said at least one PRK and optionally blocking said at least one androgen receptor-regulated mechanism in said mammalian cells.

REFERENCES:
patent: 7767411 (2010-08-01), Schuele et al.
patent: 2007/0196882 (2007-08-01), Schuele et al.
patent: 1 574 857 (2005-09-01), None
Metzger E et al: “A Novel Inducible Transactivation Domain in the Androgen Receptor: Implications for PRK in Prostate Cancer” EMBO Journal, Oxford University Press, Surrey, GB, vol. 22, No. 2, Jan. 15, 2003, pp. 270-280.
Zhu Yimin et al: “Signaling via a novel integral plasma membrane pool of a serine/threonine protein kinase PRK1 in mammalian cells.” The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology Nov. 2004, vol. 18, No. 14, Nov. 2004, pp. 1722-1724.
Preuss Ute et al: “Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase.” Nucleic Acids Research, vol. 31, No. 3, Feb. 1, 2003, pp. 878-885.
Nowak S J et al: “Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation” Trends in Genetics, Elsevier Science Publishers B.V. Amsterdam, NL, vol. 20, No. 4, Apr. 2004, pp. 214-220.
Wissmann Melanie et al: “Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression” Nature Cell Biology, Macmillan Publishers, GB, vol. 9, No. 3, Mar. 2007, pp. 347-358.
Metzger et al: “Histone demethylation and androgen-dependent transcription” Current Opinion in Genetics & Development, Current Biology Ltd, XX, vol. 16, No. 5, Oct. 2006, pp. 513-517.
Kang Z et al: “Coregulator Recruitment and Histone Modifications in Transcriptional Regulation by the Androgen Receptor” Molecular Endocrinology, Baltimore, MD, US, vol. 18, No. 11, Nov. 2004, pp. 2633-2648.
Jia Li et al: “Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells” Molecular and Cellular Biology, vol. 26, No. 19, Oct. 2006, pp. 7331-7341.
Metzger Eric et al: “Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulationx” Nature Cell Biology, vol. 10, No. 1, Jan. 2008, p. 53.
Croce L D et al: “Thrilling transcription through threonine phosphorylation” Nature Cell Biology 200801 GB, vol. 10, No. 1, Jan. 2008, pp. 5-6.
Shimada M et al: “Checkpoints meet the transcription at a novel histone milestone (H3-T11)” Cell Cycle 20080601 US, vol. 7, No. 11, Jun. 1, 2008, pp. 1555-1559.
Kang Z et al: “Involvement of Proteasome in the Dynamic Assembly of the Androgen receptor Transcription Complex”, The Journal of Biological Chemistry, vol. 277, No. 50, pp. 48366-48371, 2002.
Metzger E et al: “LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription”, Nature, vol. 437/Sep. 15, 2005, pp. 436-439.
O'Neill T et al: “Nucleosome Arrays Inhibit Both Initiation and Elongation of Transcripts by Bacteriophage T7 RNA Polymerase”, J. Mol. Biol. (1992), 223, pp. 67-78.
Dong L et al: “Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton”, PNAS, May 9, 2000, vol. 97, No. 10, pp. 5089-5094.
Strahl B et al: “The language of covalent histone modifications”, Nature, vol. 403/Jan. 6, 2000, pp. 41-45.
Wiznerowicz M et al: “Conditional Suppression of Cellular Genes: Lentivirus Vector-Mediated Drug-Inducible RNA Interference”, Journal of Virology, Aug. 2003, pp. 8957-8961.
Shang Y et al: “Formation of the Androgen Receptor Transcription Complex”, Molecular Cell, vol. 9, pp. 601-610, 2002.
Phatnani H et al: “Phosphorylation and functions of the RNA polymerase II CTD”, Genes & Development 20: 2922-2936, 2006.
Dai J et al: “The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment”, Genes & Development 19: 472-488, 2005.
Kahl P. et al: “Androgen Receptor Coactivators Lysine-Specific Histone Demethylase 1 and Four and a Half LIM Domain Protein 2 Predict Risk of Prostate Cancer Recurrence”, Cancer Res 2006, 66: (23), Dec. 1, 2006.

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