Phosphorylation of cyclic amides

Details Phosphorylation of cyclic amides Phosphorylation of cyclic amides

1986-08-15

1988-04-19

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540542, 540566, 540571, 540572, C07D24314, C07D48704

Patent

active

047390492

ABSTRACT:
Compounds of the general formula ##STR1## are reacted with a strong base followed by a phosphorylating agent, such as dicyclicaminophosphinic halide or bis-di-lower alkylaminophosphinic halide to produce an imine of the formula ##STR2## wherein R is dicyclicaminophosphinyloxy or bis-di-lower alkylaminophosphinyloxy.
R represents a leaving group which will undergo nucleophilic displacement with nitrogen, oxygen, sulfur and carbon containing nucleophiles, that is, nucleophiles which have, as a reactive site, a nitrogen, oxygen, sulfur or carbon atom, such that, when the cyclic imine undergoes nucleophilic displacement, there is formed C--N, C--O, C--S and C--C bonds between the carbon atom of the cyclic imine and the nucleophilic group.
The end products may be utilized as intermediates in the production of pharmaceutically valuable compounds and, in some instances, are pharmaceutically valuable compounds per se.

REFERENCES:
patent: 4349477 (1982-09-01), Walser et al.
Ning et al, J. Org. Chem., vol. 41, No. 16 (1976) pp. 2720-2727.

Affiliated with

Also associated with

Rating

Phosphorylation of cyclic amides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphorylation of cyclic amides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphorylation of cyclic amides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2176091