Phosphorylating agent

Details Phosphorylating agent Phosphorylating agent

1984-06-20

1987-09-08

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

548111, 548114, 548116, C07F 9146, C07F 914, C07F 965

Patent

active

046925422

ABSTRACT:
The invention relates to phosphorylating agents containing at least one protected hydroxyl group and at least one leaving group. According to the invention, a methylsulphonylethyl group (Mse) is used as the hydroxyl protecting group. Typical examples of such phosphorylating agents are the compounds (MseO).sub.2 POL, (MseO)POLL', (MseO).sub.2 PL and (MseO)PLL', in which L and L' are leaving groups. The invention also relates to processes for preparing these phosphorylating agents and processes for the phosphorylation of organic hydroxyl or amine compounds, in particular nucleosides and (poly)nucleotides.

REFERENCES:
Clark et al, "Angew. Chem." 76, (1964) pp. 704-712.
Slotin, "Synthesis," 1977, pp. 737-752.
Fourrey et al, "Tetrahedran Letters," 22, (1981) pp. 729-732.
van der Marel et al, "Tetrahedran Letters," 22, (1981) pp. 3887-3890.
van der Marel et al, "Neuleic Acid Research", 10, (1982), pp. 2337-2351.
Knorre et al, "Phosphorus Chemistry Directed Toward Biology", (1979) pp. 13-31.
van der Marel et al, "Tetrahedran Letters", 22, (1981) pp. 1463-1466.

Affiliated with

Also associated with

Rating

Phosphorylating agent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphorylating agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphorylating agent will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2159159