Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2011-08-30
2011-08-30
Wen, Sharon (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387100, C530S387300, C530S388100
Reexamination Certificate
active
08008452
ABSTRACT:
The present invention relates to the phosphorylated form of nuclear serine/threonine protein kinase, designated nuclear, Dbf2-related kinase (Ndr), and provides assays and materials for identifying modulators thereof. The invention relates to the fields of molecular biology, chemistry, pharmacology, and screening technology.
REFERENCES:
patent: 5981205 (1999-11-01), Hemmings et al.
patent: 1097989 (2001-05-01), None
patent: WO 96/19579 (1996-06-01), None
patent: WO 97/18303 (1997-05-01), None
Millward et al. (1995) Proc. Natl. Acad. Sci. USA, vol. 92, pp. 5022-5026.
Lederman et al. Molecular Immunology 28: 1171-1181, 1991.
Li et al. PNAS 77: 3211-3214, 1980.
Attwood Science 2000; 290:471-473.
Skolnick et al. Trends in Biotech. 2000; 18(1):34-39.
Campbell (Monoclonal Antibody Technology, 1984, Chapter 1, pp. 1-32).
Strausberg, et al., “Serine/threonine kinase 38 like”, Database Uniprot Online, EMBL (Jun. 1, 2002).
Strausberg, et al., Homo sapiens serine/threonine kinase 38 like, mRNA (cDNA clone MGC: 33176 Image: 4823429), PNAS, vol. 99, pp. 16899-16903 (Apr. 27, 2002).
Millward, et al., “Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins”, Embo J., vol. 17, pp. 5913-5922 (1998).
Tamaskovic, et al., “Mechanism of Ca2+-mediated regulation of Ndr protein kinase through autophorphorylation and phorphorylation by an upstream kinase”, J. of Bio. Chem., vol. 278, pp. 6710-6718 (Feb. 28, 2003).
Tamaskovic, et al., “Ndr family of AGC kinases—essential regulators of the cell cycle and morphogenesis”, FEBS Letters, vol. 546, No. 1, pp. 73-80 (Jul. 3, 2003).
Akimoto, K. et al., Atypical protein kinase C binds and regulates p70 S6 kinase, Biochem.J. 335, 417-424, (1998).
Alessi, D.R. et al., Mechanism of activation of protein kinase B by insulin and IGF-1, EMBO J. 15, 6541-6551, (1996).
Balendran, A. et al., Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms, FEBS Lett. 484, 217-223, (2000).
Behn-Krappa, A. et al., The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation, Curr. Biol. 9, 728-737, (1999).
Belham, C., et al., Intracellular signaling: PDK1—a kinase at the hub of things, Curr. Biol. 9, R93-R96, (1999).
Berridge, M.J. et al., The versatility and universality of calcium signaling, Nat. Rev. Mol. Cell Biol. 1, 11-21, (2000).
Carr, S.A. et al., Selective detection and sequencing of phosphopeptides at the femtomole level by mass spectrometry, Anal. Biochem. 239, 180-192, (1996).
Delcommenne, M. et al., Phosphoinositide-3-OH-kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B / AKT by the integrin-linked kinase, Proc. Natl. Acad. Sci. U.S.A. 95, 11211-11216, (1998).
Durrenberger, F. et al., The ukc1 gene encodes a protein kinase involved in morphogenesis, pathogenicity and pigment formation in Ustilago maydis, Mol. Gen. Genet. 261, 281-289, (1999) (Abstract Only).
Evan, G. et al., Isolation of monoclonal antibodies specific for human c-mycproto-oncogene product, Mol. Cell Biol. 5, 3610-3616, (1985).
Fujisawa, H., Regulation of the activities of multifunctional Ca2+/Calmodulin-dependent protein kinase, J.Biochem. 129, 193-199, (2001), Tokyo.
Geng, W. et al., thetricorneredgene, which is required for the integrity of epidermal cell extensions, encodes the drosophila nuclear DBF2-related kinase, Genetics 156, 1817-1828, (2000).
Haby, C. et al., Inhibition of serine/threonine protein phosphatases promotes opening of voltage-activated L-type Ca2+channels in insulin-secreting cells, Biochem.J. 298, 341-346, (1994).
Hanks et al., The protein kinase family: conserved features and deduced phylogeny of the catalytic domains, Methods in Enzymology 200, 38-62, (1991).
Hanks, S.K. et al., Science 241, 42-52, (1988).
Heierhorst, J. et al., Ca2+/S100 regulation of giant protein kinases, Nature 380, 636-639, (1996) (Abstract Only).
Hepworth, T.J. et al., Okadiac acid induces the release of Ca2+ from intracellular stores in ECV304 endothelial cells, Cell Calcium 21, 461-467, (1997) (Abstract Only).
Hill, M.M. et al., Identification of a plasma membrane raft-associated PKB Ser 473 kinase activity that is distinct from ILK and PDK1, Curr.Biol. 12, 1251, (2002).
Hill, M.M. et al., Insultin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosphorine-insensitive kinase, J.Biol.Chem. 276, 25643-25646, (2001).
ILG, E.C. et al., Expression pattern of S100 calcium-binding proteins in human tumors, Int.J.Cancer 68, 325-332, (1996).
Jaspersen, S.L. et al., A late mitotic regulatory network controlling cyclin destruction insaccharamyces cerevisiae, Mol. Biol. Cell 9, 2803-2817, (1998).
Johnston, L.H. et al., The product of thesaccaromyces cerevisiaecell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle, Mol.Cell.Bio1.10, 1358-1366, (1990).
Justice, R.W. et al., TheDrosphiliatumor suppressor genewartsencodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation, Genes & Development 9, 534-546, (1995).
Knighton, D.R. et al. Crystal structure of the catalytic subunit of cyclic adenosine momophosphate-dependent protein kinase, Science 253, 407-414, (1991).
LeGood, J.A. et al., Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1, Science 281, 2042-2045, (1998).
Leslie, N.R. et al., Phosphoinositide-regulated kinases and phosphoinositide phosphatases, Chem.Rev. 101, 2365-2380, (2001).
Lynch, D.K. et al., Integrin-linked kinase regulated phosphorylation of serine 473 of protein kinase B by an indirect mechanism, Oncogene 18, 8024-8032, (1999).
Millward, T.A. et al., Ndr protein kinase is regulated by phosphorylation on two conserved sequence motifs, J.Biol.Chem.274, 33847-33850, (1999).
Newton, A.C., Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions, Chem.Rev. 101, 2353-2364, (2001).
Parker, P.J. et al., AGC protein kinase phosphorylation and protein kinase C, Biochem.Soc.Trans. 29, 860-863, (2001).
Peterson, R.T. et al., Kinase phosphorylation: keeping it all in the family, Curr.Biol. 9, R521-R524, (1999).
Racki, W.J. et al., Cbk1p, a protein similar to the human myotonic dystrophy kinase, is essential for normal morphogenesis inSaccaromyces cerevisiae, EMBO J. 19, 4524-4532, (2000).
Romanelli, A. et al., p70 S6 kinase is regulated by protein kinase C and participates in a phosphoinositide 3-kinase regulated signalling complex, Mol. Cell Biol. 19, 2921-2928, (1999).
Shaw, M. et al., The activation of protein kinase B by H202or heat shock is medicated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2, Biochem. J. 336, 241-246, (1998).
Smith, D.B. et al., Single-step purification of polypeptides expressed inEscherichia coilas fusions with glutathione S-transferase, Elsevier B.V. (1988) (Abstract Only).
St. John, M.A.R. et al., Mice deficient ofLats1develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction, Nature Genetics 21, 182-186, (1999).
Tao, W. et al., Human homologue of theDrosophila melanogaster latstumour suppressor modulates CDC2 activity, Nature Genetics 21, 177-181, (1999).
Taylor, C.W. et al., Pharmacological analysis of intracellular Ca2+signaling: problems and pitfalls, Trends Pharmacol. Sci. 19, 370-375, (1998).
Toyn J.H. et al., The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition, EMBO J. 13, 1103-1113, (1994).
Treiman, M. et al., A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, Trends Pharmacol. Sci. 19, 131-135 (1998).
Tripodis, N. et al., Construction of a high-resolution 2.5-Mb transcript map of the human 6p21.2-6p21.3 region immediately centromeric of the major hi
Bichsel Samuel Joseph
Hemmings Brian Arthur
Stegert Mario Reinhard
Tamaskovic Rastislav
Hoxie & Associates LLC
Novartis Forschungesstiftung, Zweigniederlassung Friedrich Miesc
Wen Sharon
LandOfFree
Phosphorylated Ndr kinase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phosphorylated Ndr kinase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphorylated Ndr kinase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2739298