Phosphorylated glycosidase inhibitor prodrugs

Details Phosphorylated glycosidase inhibitor prodrugs Phosphorylated glycosidase inhibitor prodrugs

1989-08-17

1991-08-27

Brown, Johnnie R.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing organic compound containing a metal or atom other...

435193, 435194, 435196, 435255, 514329, 514315, 548526, C12P 900, C07P20740, C12N 912, C12N 916

Patent

active

050432737

ABSTRACT:
A method is provided for converting therapeutic glycosidase inhibitors to novel prodrugs by phosphorylation of a free hydroxyl group on the molecule to substantially reduce the glycosidase inhibitory activity without thereby substantially reducing the therapeutic activity.

REFERENCES:
patent: 4065562 (1977-12-01), Ohata et al.
patent: 4182767 (1980-01-01), Murai et al.
patent: 4847244 (1989-07-01), Rideout et al.
patent: 4849430 (1989-07-01), Fleet et al.
Fleet et al., Febs Lett. 237, 128-132 (1988).
Karpas et al., Proc. Natl. Acad. Sci. U.S.A. 85, 9229-9233 (1988).
Drueckhammer and Wong, J. Org. Chem. 50, 5912-5913 (1985).
Al-Nakib et al., J. Antimicrobiol, Chemother, 20, 887-892 (1987).
Phillpotts et al., J. Antimicrobial Chemother, 14, 403-409 (1984).
Kim and Raushel, Biochemistry 27, 7328-7332 (1988) (Sep. 20, 1988).
Stanek et al., The Monosaccharides, Academic Press, 1963, pp. 229-236.
Koreeda et al., J. Org. Chem. 50 (1985), pp. 5912-5913.

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