Phosphorylated derivatives of L-dopa and compositions and method

Details Phosphorylated derivatives of L-dopa and compositions and method Phosphorylated derivatives of L-dopa and compositions and method

1989-04-07

1992-03-31

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

514114, 514118, 548112, 558178, 560 9, 560 40, 562 9, 562 10, 562 11, 568442, A61K 742, C07F 906, C07F 922, C07F 938

Patent

active

051006545

ABSTRACT:
A phosphorylated derivative of L-dopa of the formula ##STR1## wherein when X is ##STR2## wherein Z is --CH.sub.2, N, S or a linkage other than oxygen which renders the phosphate group resistant to hydrolysis by phosphatase enzymes in tissues and biological fluids,
then Y is OQ, wherein Q is H or an alkyl with one to twelve carbon atoms, or
wherein X is OQ, then Y is ##STR3## wherein R' is hydrogen or a pharmaceutically acceptable cation and R is a moiety which increases hydropobicity. The phosphorylated derivative of L-dopa is useful as an agent to increase the melanin content in mammalian skin and hair.

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