Phosphorylated derivatives of cardiodilatin/ANF peptides

Details Phosphorylated derivatives of cardiodilatin/ANF peptides Phosphorylated derivatives of cardiodilatin/ANF peptides

1993-07-22

1995-10-24

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

514 7, 514 12, 514 21, 530334, 530345, 530352, 530408, 530410, 930 50, 930DIG554, A61K 3822, C07K 104, C07K 1113, C07K 1458

Patent

active

054611423

ABSTRACT:
Described are derivatives of the precursor peptide of the cardiodilatin/atrial sodiuretic factor (CDD-ANF) or fragments thereof which comprise at least the amino acid sequence of alpha-hANaP. The derivatives according to the present invention are compounds of the formula (I) ##STR1## X is a phosphate or thiophosphate group. R is NH.sub.2 or a peptide fragment from the amino acid sequence of gamma-hANaP. Radio-labelled derivatives are also possible. A method for the qualitative and/or quantitative determination of peptides containing the sequence of alpha-hANaP and a use of the compounds having the formula (I) as medicaments for various vaso- and renal related disorders are further described.

REFERENCES:
patent: 4508712 (1985-04-01), Needleman
Bloch et al, "Proatrial Natriuretic Factor is Phosphorylated by Rat Cardiocytes in Culture". J. Biol. Chem. 262(21), Jul. 25, 1987, pp. 9956-9961.
Olins et al, "Phosphorylation of high-and low-molecular-mass atrial natriuretic peptide analogs . . . ". FEBS Lett. 224(2), Nov. 1987, pp. 325-330.
Rittenhouse et al, "Phosphorylation of Atrial Natriuretic Peptides by Cyclic AMP-dependent Protein kinase." J. Biol. Chem. 261(17), Jun. 15, 1986, pp. 7607-7610.
Rittenhouse et al, "Phosphorylation in Situ of Atrial Natriuretic Peptide Prohormone . . . ". J. Biol. Chem. 263(8), Mar. 15, 1988, pp. 3778-3783.
Chemical Abstracts, vol. 105, 1986, p. 138, No. 73295w.
Chemical Abstracts, vol. 108, 1988, p. 148, No. 49972f.
Chemical Abstracts, vol. 108, 1988 p. 156, No. 144184j.
Chemical Abstracts, vol. 107, 1987, p. 157, No. 127948y.

Affiliated with

Also associated with

Rating

Phosphorylated derivatives of cardiodilatin/ANF peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphorylated derivatives of cardiodilatin/ANF peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphorylated derivatives of cardiodilatin/ANF peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1887589