Phosphorylated derivatives of a U1-70K peptide and their use...

Details Phosphorylated derivatives of a U1-70K peptide and their use... Phosphorylated derivatives of a U1-70K peptide and their use...

2011-01-18

2011-01-18

Ewoldt, G. R (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

Reexamination Certificate

active

07872098

ABSTRACT:
Derivatives of the peptide corresponding to the sequence RIHMVYSKRSGKPRGYAFIEY (SEQ ID NO: 1), pharmaceutical compositions, and methods of use thereof are provided.

REFERENCES:
patent: WO 03/020747 (2003-03-01), None
Monneaux, F., et al. J. Immunol. 2001;175:5839-5847.
Brahms Hero et al: “The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-ell epitope for anti-Sm Autoantibodies.” Journal of Biological Chemistry, vol. 275, No. 22, Jun. 2, 2000, pp. 17122-17129, XP002202537.
Monneaux Fanny et al: “B and T cell immune response to small nuclear ribonucleoprotein particles in lupus mice: Autoreactive CD4+ T cells recognize a T cell epitope located within the RNP80 motif of the 70K protein.” European Journal of Immunology, vol. 30, No. 8, Aug. 2000, pp. 2191-2200, XP002202538.
Monneaux F et al: “Key sequences involved in the spreading of the systemic autoimmune response to spliceosomal proteins.” Scandinavian Journal of Immunology, vol. 54, No. 1-2, Jul. 2001, pp. 45-54, XP002202539.

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