Phosphorus prodrugs

Details Phosphorus prodrugs Phosphorus prodrugs

1996-12-11

1998-08-04

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

560 8, 560 76, 568 8, 568 13, 568 14, C07D41300

Patent

active

057896089

ABSTRACT:
The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorous bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and into tissues in vivo. Prodrugs for a variety of antiviral and anti-leukemic agents are described.

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