Phosphorus containing peptides, pharmaceutical compositions and

Details Phosphorus containing peptides, pharmaceutical compositions and Phosphorus containing peptides, pharmaceutical compositions and

1988-11-14

1990-06-19

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

562 15, A61K 3702, C07K 502, C07K 506

Patent

active

049354043

ABSTRACT:
Novel compounds of the formula (I), a process for their preparation and their use as collagenase inhibitors are described: ##STR1## in which R.sub.1 is hydrogen or hydroxy; R.sub.2 is hydrogen or alkyl; R.sub.3 is C.sub.3-6 alkyl; R.sub.4 is hydrogen, alkyl, --CH.sub.2 --Z where Z is optionally substituted phenyl or heteroaryl, or R.sub.4 is a group ##STR2## where R.sub.8 is hydrogen, alkyl or --CH.sub.2 --Ph where Ph is optionally substituted phenyl, and R.sub.9 is hydrogen or alkyl; and R.sub.5 is hydrogen or alkyl.

REFERENCES:
patent: 3950402 (1976-04-01), Franz
patent: 4016148 (1977-04-01), Atherton et al.
patent: 4213969 (1980-07-01), Baylis et al.
patent: 4331591 (1982-05-01), Baylis
patent: 4389349 (1983-06-01), Cho et al.
patent: 4661298 (1987-04-01), Mirviss et al.
patent: 4804500 (1989-02-01), Miller
Review Article Collagenase Inhibtors: Their Design and Potential Therapeutic Use.
W. H. Johnson, N. A. Roberts and N. Borkakoti, Roche Products Limited, P.O. Box 8, Welwyn Garden City, Hertz AL7 3AY, UK.
(Received Jun. 9, 1987), J. Enzyme Inhibition, 1987, vol. 2, pp. 1-22; 1987 Harwood Academic Publishers GmbH Great Britain.

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