Phosphorus-containing dendrimers as transfection agents

Details Phosphorus-containing dendrimers as transfection agents Phosphorus-containing dendrimers as transfection agents

2005-11-29

2005-11-29

McKelvey, Terry (Department: 1636)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C424S400000, C424S078170, C514S772100, C514S04400A, C564S012000, C564S284000, C564S386000

Reexamination Certificate

active

06969528

ABSTRACT:
The invention concerns phosphorus-containing dendrimers and their uses, as gene transfection agents, in vitro and in vivo, including in the treatment of human and animal diseases. These agents or vectors are in particular suited for delivering to appropriate target cells, nucleic acid sequences of interest.

REFERENCES:
patent: 6440405 (2002-08-01), Cooper et al.
patent: WO 95 02397 (1995-01-01), None
Launay et al. Synthesis of bowl-shpaed dendrimers from generation 1 to generation 8. Journal of Organometallic Chemistry, vol. 529, pp. 51-58, 1997.
Prevote et al. Phosphate-, phosphite-, Ylide-, and phosphonate-terminated dendrimers. Journal of Organic Chemistry, vol. 62, pp. 4834-4841, 1997.
C. Galliot; “Regioselective Stepwise Growth Of Dendrimer Units In The Internal Voids Of A Main Dendrimer”; Sep. 26, 1997; pp. 1981-1984; vol. 277; SCIENCE; Lancaster, PA.
C. Larre; “Phosphorus-Containing Dendrimers: Chemoselective Functionalization of Internal Layers”; Apr. 29, 1998; pp. 4029-4030; vol. 120, No. 16; American Chemical Society; Washington, D.C.
D. Prevote; “Phosphate-, Phosphite-, Ylide-, and Phosphonate-Terminated Dendrimers”; Jul. 11, 1997; pp. 4823-4841; vol. 62, No. 14; Journal of Organic Chemistry.
C. Loup; “Preparation of Water-Soluble Cationic Phosphorus-Containing Dendrimers as DNA Transfecting Atents”; Dec. 1999; pp. 3644-3650; vol. 5, No. 12; VCH Publishers.
V. Maraval; “Rapid Synthesis of Phosphorus-Containing Dendrimers with Controlled Molecular Architectures: First Example of Surface-Block, Layer-Block, and Segment-Block Dendrimers Issued from the Same Dendron”; Mar. 22, 2000; pp. 2499-2511; vol. 122, No. 11; Journal of the American Chemical Society.

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