Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-08-15
2006-08-15
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C540S456000
Reexamination Certificate
active
07091213
ABSTRACT:
This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which:A is absent or is —O—, —S— or —NR2—;Q is absent or (if A is —O—, —S— or —NR2—) Q may be —V—, —OV—, —SV—, or —NR2V—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NR2VA;K is O or S;each occurrence of Y is independently —O—, —S—, —NR2—, or a bond linking a R5moiety to P;each occurrence of R2and R5is independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; andeach occurrence of R6is independently —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5); so long as any R2, or R5moiety linked directly to P is not H;wherein two R2, R5and/or R6moieties may be chemically linked to one another to form a ring;each occurrence of G is independently —O—, —S—, —NR2— or (M)x;each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M′ moiety may be saturated or unsaturated;each occurrence of x is independently an integer from 1–6; and the other variables are as defined herein.
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Berstein David L.
Metcalf, lll Chester A.
Rozamus Leonard W.
Wang Yihan
ARIAD Gene Therapeutics, Inc.
Berstein David L.
Kifle Bruck
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