Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1986-10-30
1989-02-28
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 28, 536 29, C07H 1700
Patent
active
048087084
ABSTRACT:
Novel phosphorsulfide derivatives of deoxynucleosides or deoxynucleotides are provided, which have the general formula: ##STR1## wherein R.sup.1 is a hydroxy-protecting group; R.sup.2 is a phosphate-protecting group; R.sup.3 is an aryl group; B.sub.1 and B.sub.2 may be the same or different and each are a base residue which may have a protecting group; and n is zero or a positive integer, provided that if n is 2 or larger, the respective R.sup.2 may be the same or different. They are prepared by reacting a deoxynucleoside or deoxynucleotide with a 1,2,4-triazolylphosphine compound and are useful as intermediates for the preparation of oligodeoxy-nucleotides.
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Mitsubishi, Chem. Abstr., 98:54407e, 54408f, p. 723, 1983.
Kimura Kaoru
Yoshida Tadao
Brown Johnnie R.
Crane L. Eric
Toagosei Chemical Industry Co. Ltd.
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