Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1996-09-30
1998-05-12
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514458, 549220, 549222, 549408, 549477, A61K 31665, A61K 31355, C07F 906, C07F 928
Patent
active
057505160
ABSTRACT:
This invention provides a phosphoric diester of formula (I) which is available on di-esterification of phosphoric acid with L-ascorbic acid involving its 5-hydroxyl group and tocopherol involving its hydroxyl group or a pharmacologically acceptable salt thereof. ##STR1## The compound of the invention can be used with advantage as an antioxidant (radical-scavenging) agent and a prophylactic and therapeutic agent for ischemic organ disorders (e.g. myocardial infarction, heart failure, arrhythmia, cerebral infarction, stroke (cerebral apoplexy), renal failure, etc.).
REFERENCES:
patent: 4564686 (1986-01-01), Ogata
patent: 4948786 (1990-08-01), Shimamoto et al.
patent: 5306713 (1994-04-01), Suetsugu et al.
Iemura Masahito
Nakamura Masayuki
Ogata Kazumi
Saito Noriko
Sakaue Takahiro
Huang Evelyn
Ivy C. Warren
Senju Pharmaceutical Co. Ltd.
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