Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1997-08-28
1998-06-09
Geist, Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
562553, 562560, 562562, 5483391, 426807, C07C22900, A23K 118
Patent
active
057636575
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a novel phosphoric acid-amino acid-polyvalent metal composite salt and a ruminant feed additive composition containing the same as an active ingredient. The ruminant feed additive composition of the present invention can be stable in a rumen of a ruminant and release a basic amino acid in an abomasum and lower digestive organs, and it can take the form of a powder or granules.
TECHNICAL BACKGROUND
When biologically active substances such as amino acids, vitamins and the like are orally administered directly into ruminants such as cow, sheep and the like, most of these substances are decomposed with microorganisms in the rumen, and are, therefore, not utilized effectively. Accordingly, rumen by-pass preparations for use in the ruminants by which these biologically active substances are protected from the decomposition with microorganisms in the rumen but are digested and absorbed in the abomasum and lower digestive organs are important in the field of ruminant feed, nutrients, chemicals and the like.
With respect to ruminant feed additives containing a biologically active substance, a method in which a biologically active substance is dispersed in a matrix formed of a hydrophobic substance such as fats and oils or a protective substance such as a basic high-molecular substance, and the dispersion is granulated, or a method in which a core containing a biologically active substance is coated with a hydrophobic substance such as fats and oil or an acid-sensitive substance such as a basic high-molecular substance has been proposed so far.
Concerning the method in which the biologically active substance is dispersed in the protective substance, for example, Japanese Laid-Open No. 168,351/1985 proposes a method which comprises mixing a biologically active substance with at least 20% by weight of calcium carbonate and at least 10% by weight of an aliphatic monocarboxylic acid having 14 or more carbon atoms, hardened fats and oils or the like, and pulverizing the mixture. Japanese Patent Publication No. 10,780/1984 proposes a method which comprises dispersing from 30 to 50% by weight of a biologically active substance in a protective substance comprising from 10 to 35% by weight of a salt of an aliphatic monocarboxylic acid having from 14 to 22 carbon atoms or ricinoleic acid and the remainder of an aliphatic monocarboxylic acid having from 14 to 22 carbon atoms, ricinoleic acid or hardened fats and oils.
Concerning the method in which the biologically active substance is coated with the hydrophobic protective substance, for example, Japanese Kokai No. 317,053/1988 proposes a method in which a biologically active substance is coated with a protective agent composed of an aliphatic monocarboxylic acid having from 12 to 24 carbon atoms, hardened fats and oils, lecithin and a glycerin fatty acid ester.
Concerning the method in which the biologically active substance is coated with the acid-sensitive protective substance, for example, Japanese Kokai No. 46,823/1979 proposes a method in which a biologically active substance is coated with a coating composition containing a film-forming basic high-molecular substance. Japanese Kokai No. 217,625/1992 proposes a method in which a biologically active substance is spray-coated with casein in the form of an aqueous emulsion or an aqueous dispersion.
However, in the method in which the biologically active substance is dispersed into the protective substance and the dispersion is pulverized, the biologically active substance is present near surfaces of particles obtained. Accordingly, when the protection is taken seriously, the content of the biologically active substance has to be notably decreased. Since the residence time of the water-soluble biologically active substance in the rumen is between 10-odd hours and several days, this biologically active substance can hardly be protected sufficiently.
Further, a method in which a biologically active substance-containing core is coated with an acid-sensitive high-molecular sub
REFERENCES:
patent: 5676966 (1997-10-01), Kitamura et al.
Hijiya Toyoto
Ikeda Toru
Kamada Hajime
Mori Ken-ichi
Takemoto Tadashi
Ajinomoto Co. Inc.
Geist Gary
Keys Rosalynd
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