Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1988-04-06
1994-06-28
Rollins, John W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2534, 536 268, C07H 100
Patent
active
053248317
ABSTRACT:
5,6-dihydro-5-azacytidine phosphoramidite is useful in the synthesis of oligonucleotides and DNA containing dihydro-5-aza- and 5-azacytosine bases. The modified oligonucleotides which contain 5-azacytosine residues at specific sites can be used to determine the mechanism of selective gene activation and the relationship existing between the presence of the triazine base and inhibition of DNA methylation.
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McBride et al., "Amidine Protecting Groups for Oligonucleotide Synthesis," J. Am. Chem. Soc., 1986, vol. 108, 2040-48.
Piskala et. al., "Nucleic Acids Components and their Analogues Synthesis of 1-Glycoxyl Derivatives of 5-azauracil and 5-azacytosine," Coll. Czech Chem. Comm., vol. 29, pp. 2060-2076 (1964).
Goddard Amanda J.
Marquez Victor E.
Rollins John W.
The United States of America as represented by the Secretary of
Wilson James O.
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