Phosphoramidite derivatives, their preparation and the use there

Details Phosphoramidite derivatives, their preparation and the use there Phosphoramidite derivatives, their preparation and the use there

1995-03-20

1999-01-26

Elliott, George G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2532, 536 231, 435 6, C07H 2100, C07H 1900

Patent

active

058640320

ABSTRACT:
Phosphoramidite derivatives of formula (V), ##STR1## wherein X is biotin and Y is a protecting group. There may be a linker arm, of variable length, between X and the rest of the molecule. Examples of the protecting group Y include 4,4'-dimethoxytrityl, trifluoroacetyl and fluorenylmethoxycarbonyl (Fmoc). The phosphoramidite derivatives are useful in single or multiple labelling of synthetic oligonucleotides. Process for the preparation of these phosphoramidite derivatives are also disclosed.

REFERENCES:
Alves et al., Tetrahedron Letters, 30(23):3089-3092, 1989.
Misiura et al., Nuc. Acids Res., vol. 18, No. 15, pp. 4345-4354 (1990).
Nelson et al., Nuc. Acids Res., vol. 17, No. 18, pp. 7179-7186 (1989).

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