Phosphoramidite derivatives of texaphyrins

Details Phosphoramidite derivatives of texaphyrins Phosphoramidite derivatives of texaphyrins

1996-03-13

1997-05-27

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Rare earth containing

534 11, 534 13, 534 16, 536 171, 536 173, 536 174, 540145, 540465, 540472, C07F 700, C07F 96524, C07D18722

Patent

active

056333544

ABSTRACT:
The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer to form an expanded porphyrin-oligonucleotide conjugate, and particularly a sapphyrin- or texaphyrin-oligonucleotide conjugate. This method includes reacting derivatized nucleotides and a sapphyrin or a texaphyrin in a desired order in an automated or manual DNA synthesizer having a solid support to form a sapphyrin- or a texaphyrin-oligonucleotide conjugate.

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