Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1996-03-26
1999-09-28
McKane, Joseph K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 80, 514 82, 514 89, 514 91, 514 94, 514 95, 514 96, 514 99, 514 85, 514100, 544243, 546 22, 546 23, 548115, 548113, 548413, 549 6, 549218, 549220, A61K 3142, C07D26114
Patent
active
059589051
ABSTRACT:
Phosphoramidates and phosphinic amides and related compounds are provided. Also provided are methods that use the compounds for modulating the activity of the endothelin family of peptides are provided. In particular, compounds having formula: ##STR1## in which A, B, R.sup.1 and R.sup.2 are as described are provided. Also provided are methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these compounds or prodrugs thereof. Methods for elucidating the physiological and pathophysiological roles of endothelin, as well as isolating endothelin receptors are also provided.
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Chan Ming Fai
Verner Erik Joel
McKane Joseph K.
Seidman Stephanie L.
Texas Biotechnology Corporation
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