Phosphopeptides and methods of treating bone diseases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 12, 514143, 530324, 530330, 530352, 436 86, 436103, A61K 3800, A61K 3804, A01N 5710, C07K 500

Patent

active

058376747

ABSTRACT:
Phosphopeptides which significantly reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with bone loss or weakening by administering the phosphopeptides by oral or injectable means.

REFERENCES:
patent: 5015628 (1991-05-01), Reynolds
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Linde, A., et al., "Mineral Induction by Immobilized Proteins." Calcif. Tissue Int. (1989) 44:286-295.
Lufkin, E.G., et al., "Pamidronate: An Unrecognized Problem in Gastrointestinal Tolerability." Osteoporos Int. (1994) 4(6): 320-322.
Lussi, A., et al., "Induction and Inhibition of Hydroxyapatite Formation by Rat Dentine Phosphoprotein." Arch Oral Biol. (1988) 33:685-691.
Nawrot, C.F., et al., "Dental Phosphoprotein-Induced Formation of Hydroxyapatite during in Vitro Synthesis of Amorphous Calcium Phosphate." Biochemistry (1976) 51:3445-9.
van den Bos, T. et al., "Effect of Bound Phosphoproteins and Other Organic Phosphoproteins and Other Organic Phosphates on Alkaline Phosphatase-Induced Mineralization of Collagenous Matrices in Virtro." Bone and Mineral (1993) 23:81-93.

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