Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Reexamination Certificate
2007-03-20
2007-03-20
Slobodyansky, Elizabeth (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
C435S069100, C435S131000, C435S193000, C435S252300, C435S254110, C435S254200, C435S348000, C435S410000, C530S326000, C530S329000, C536S023200, C536S023700
Reexamination Certificate
active
10261049
ABSTRACT:
The invention pertains to isolated phosphopantetheinyl transferases, such as theE. coliacyl carrier protein synthase, which transfer a phosphopantetheinyl group onto a substrate. The enzyme can be purified from a natural source, produced recombinantly, or synthetically. Accordingly, the invention provides compositions and kits including phosphopantetheinyl transferases and host cells expressing phosphopantetheinyl transferases. The invention also provides nucleic acids encoding phosphopantetheinyl transferases and vectors comprising such nucleic acids. The invention further provides methods for phosphopantetheinylating a substrate in vitro or in vivo and methods for producing antibiotics in vitro or in vivo.
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Gehring Amy M.
Lambalot Ralph H.
Reid Ralph
Walsh Christopher T.
Lahive & Cockfield LLP
President & Fellows of Harvard College
Slobodyansky Elizabeth
The Regents of the University of California
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