Phosphonomonoester nucleic acids process for their preparation a

Details Phosphonomonoester nucleic acids process for their preparation a Phosphonomonoester nucleic acids process for their preparation a

1998-11-20

2000-10-03

Riley, Jezia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 1, 435 5, 435 6, 536 221, 536 231, 536 243, 536 253, 536 2532, A01N 4304, C12Q 170, C12Q 168, C07H 1900, C07H 2102

Patent

active

061273465

ABSTRACT:
Novel oligonucleotide analogs of the formula [I] are described, ##STR1## in which A, B, D, G, L, P, Q, Q', R.sup.5, R.sup.6, X, Y, Z and n are as defined in the description, which have useful physical, biological and pharmacological properties, as well as a process for their preparation. Their application relates to use as inhibitors of gene expression (antisense oligonucleotides, ribozymes, sense oligonucleotides and triplex-forming oligonucleotides), as probes for the detection of nucleic acids and as auxiliaries in molecular biology.

REFERENCES:
patent: 4344949 (1982-08-01), Hoefle et al.
patent: 4350704 (1982-09-01), Hoefle et al.
patent: 4374847 (1983-02-01), Gruenfeld
patent: 5166394 (1992-11-01), Breipohl et al.
patent: 5264562 (1993-11-01), Matteucci

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