Phosphonoformic acid esters and pharmaceutical compositions cont

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

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260941, A61K 3166, C07F 940

Patent

active

043860818

ABSTRACT:
A pharmaceutical preparation containing as active ingredient a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different, and each is selected from the group consisting of hydrogen, alkyl groups containing 1-6 carbon atoms; cycloalkyl groups containing 3-6 carbon atoms; cycloalkyl-alkyl groups containing 4-6 carbon atoms; 1-adamantyl; 2-adamantyl, benzyl; and phenyl groups of the formula ##STR2## wherein R.sub.4 and R.sub.5 are the same or different and each is selected from the group consisting of hydrogen, halogen, alkyl having 1, 2, or 3 carbon atoms, alkoxy having 1, 2, or 3 carbon atoms, alkoxycarbonyl having 2-7 carbon atoms and alkylcarbonyl groups having 2-7 carbon atoms; or R.sub.4 and R.sub.5 together form a straight saturated alkylene chain having 3 or 4 carbon atoms and being bound to adjacent positions, i.e. 2,3- or 3,4- in the phenyl ring;

REFERENCES:
patent: 3767795 (1973-10-01), Schleicher et al.
patent: 3943201 (1976-03-01), McIntosh
patent: 4052439 (1977-10-01), Herrin et al.
patent: 4092412 (1978-05-01), Maod et al.
patent: 4215113 (1980-07-01), Eriksson et al.
Helgstrand, et al. "Science" vol. 201, (1978) 819-821.
Shipkowitz, et al. "Applied Microbiology" Sep. 1973, pp. 264-267.
Unlisted Drugs, vol. 17, (1965) (No. 12), HC 8020 (m), p. 89.

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