Chemistry of carbon compounds – Dipeptides – e.g. – aspartame – anserine – carnosine – etc.
Patent
1979-11-13
1983-02-08
Sutto, Anton H.
Chemistry of carbon compounds
Dipeptides, e.g., aspartame, anserine, carnosine, etc.
260924, 544110, 424210, 424199, C07F 940, A61K 3166
Patent
active
043728944
ABSTRACT:
A compound of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different, and each is selected from the group consisting of hydrogen and phenyl groups of the formula ##STR2## wherein R.sub.4 and R.sub.5 are the same or different and each is selected from the group consisting of hydrogen, halogen, alkyl having 1, 2, or 3 carbon atoms, alkoxy having 1, 2, or 3 carbon atoms, alkoxycarbonyl having 2-7 carbon atoms; and alkylcarbonyl groups having 2-7 carbon atoms; or R.sub.4 and R.sub.5 together from a straight saturated alkylene chain having 3 or 4 carbon atoms and being bound to adjacent positions, i.e. 2,3- or 3,4- in the phenyl ring; provided that one of R.sub.1 and R.sub.2 is a phenyl group of the formula II when R.sub.3 is H; and physiologically acceptable salts and optical isomers thereof; methods for preparation of the compounds, pharmaceutical compositions containing them, and their medicinal use.
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Helgstrand Ake J. E.
Johannson Karl N.
Misiorny Alfons
Noren Jan O.
Stening Goran
Astra Lakemedel Aktiebolag
Sutto Anton H.
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