Phosphono substituted tetrazole derivatives as ECE inhibitors

Details Phosphono substituted tetrazole derivatives as ECE inhibitors Phosphono substituted tetrazole derivatives as ECE inhibitors

1995-03-02

1996-08-27

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

C07F 9280

Patent

active

055501192

ABSTRACT:
The present invention relates to the N-phosphonomethyl substituted compounds of formula ##STR1##

REFERENCES:
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patent: 5294632 (1994-03-01), Erion et al.
CA 121:281220a Preparation . . . inhibitors. Erion et al., pp 1091, 1994.
Chem Abst. 117(7):70275b, Nachev, 1991.
K. Shiosaki et al. DN&P 7(10) Dec. 1994 pp.593-601.
T. Fukami et al. Biorganic & Medicinal Chem. letters vol. 4, No. 10 pp. 1257-1262 (1994).
S. De Lambert et al. Biochemical & Biophysical Research Comm. vol. 204, No. 1 (1994) Oct. 14, 1994.
B. Weiss et al. Res. Comm. in chemical Pathology & Pharmacology vol. 52, No. 1 Apr. 1986.
FASEB Journal Absts Endothelin/Endothelin Receptors, Mar. 15, 1994, A184.

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