Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1988-10-21
1991-03-05
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
546 23, C07F 960, A61K 31675
Patent
active
049978217
ABSTRACT:
A class of phosphono-hydroisoquinoline componds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a phosphono-hydroisoquinoline compound alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sup.1 through R.sup.4 is hydrido, each of Z.sup.1 and Z.sup.2 is hydroxyl and wherein the A ring is aromatic.
REFERENCES:
patent: 4746653 (1988-05-01), Hutchison et al.
March, Advanced Organic Chemistry, Reactions, Mechanisms and Structure, Second Edition, p. 462 McGraw Hill Pub. (1979).
Cordi Alexis A.
Vazquez Michael L.
Keane J. Timothy
Matukaitis Paul D.
Rotman Alan L.
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