Phosphonic diester derivatives

Details Phosphonic diester derivatives Phosphonic diester derivatives

2007-08-21

2007-08-21

Berndhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

C514S266200, C514S266300, C514S266400, C544S081000, C544S087000, C544S244000, C544S287000

Reexamination Certificate

active

10838297

ABSTRACT:
The present invention provides a phosphonic acid diester compound represented by General Formulawherein R1, R2, R3and R4are the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; R5is phenyl having on the phenyl ring 1–3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that R5is not mono(lower alkoxy)pheny; and R6is lower alkyl;and an ACAT-1 inhibitor containing the compound as an active ingredient.

REFERENCES:
patent: 5798344 (1998-08-01), Kuroki et al.
patent: 08-143586 (1996-06-01), None
Inoue et al, “Antiatherogenic Effects of a Novel Selective Acyl-CoA: Cholesterol Acyltransferase-1 Inhibitor, OT-13398, in the Rat Carotid Artery with Experimental Altherosclerosis”, 4thAnnual Conference on Arterioschlerosis, Thrombosis and Vascular Biology, The American Heart Association, P74 (May 8-10, 2003).

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