Phosphonic acid substituted aromatic steroids as inhibitors of s

Details Phosphonic acid substituted aromatic steroids as inhibitors of s Phosphonic acid substituted aromatic steroids as inhibitors of s

1988-12-23

1989-11-21

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 75, 514 79, 514 85, 514 86, 514 90, 514 91, 514 92, 514100, 514113, 514125, 514130, 514141, 540 23, 540 95, 540100, 260397, 2603973, 2603974, 26039745, 2603975, A61K 3166, A61K 31665, A61K 31675, C07J 100

Patent

active

048823198

ABSTRACT:
Invented are phosphonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase, including using these compounds to reduce or maintain prostate size. Also invented are intermediates used in preparing these compounds.

REFERENCES:
J. Am. Chem. Soc., 1987; 109; pp. 2831-2833; Petrakis et al.

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