Phosphonate, phosphinate derivatives useful as antihypertensive

Details Phosphonate, phosphinate derivatives useful as antihypertensive Phosphonate, phosphinate derivatives useful as antihypertensive

1991-01-31

1992-10-06

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

548119, 549218, 558180, 558182, 558188, 558189, 558190, 558192, 558193, 558196, 558197, 558198, 568 15, C07F 932, C07F 940, C07F 953

Patent

active

051533472

ABSTRACT:
Novel angiotensin II receptor antagonists of the formula ##STR1## wherein X, X.sub.1, X.sub.2, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein, are disclosed. These compounds are useful, for example, in the treatment of hypertension, congestive heart failure and cardiac hypertrophy.

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