Phosphonate-nucleotide ester derivatives

Details Phosphonate-nucleotide ester derivatives Phosphonate-nucleotide ester derivatives

1997-10-02

2000-03-14

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 81, 544244, A61K 31675, C07F 96512

Patent

active

060373350

ABSTRACT:
Phosphonate-nucleotide ester compounds of the formula (I) have excellent antiviral activity and antineoplastic activity. Further, they can be orally administered. ##STR1## wherein ring A represents ##STR2## wherein R.sup.1 and R.sup.2 independently represent hydrogen, halogen, hydroxyl, mercapto, C.sub.6 -C.sub.10 arylthio or amino; R.sup.3 represents C.sub.1 -C.sub.4 alkyl or ethyl having one or more substituents selected from the group consisting of fluorine, C.sub.1 -C.sub.4 alkoxy, phenoxy, C.sub.7 -C.sub.10 phenylalkoxy and C.sub.2 -C.sub.5 acyloxy; R.sup.4 represents ethyl having one or more substituents selected from the group consisting of fluorine, C.sub.1 -C.sub.4 alkoxy, phenoxy, C.sub.7 -C.sub.10 phenylalkoxy and C.sub.2 -C.sub.5 acyloxy; X, Y and Z independently represent methyne or nitrogen atom; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 5663159 (1997-09-01), Starrett, Jr. et al.
patent: 5840716 (1998-11-01), Ubasawa et al.
Drug Evaluations by American Medical Association p 1861-1862 (1993).

Affiliated with

Also associated with

Rating

Phosphonate-nucleotide ester derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphonate-nucleotide ester derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphonate-nucleotide ester derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-169349